NALT

Preferred term

patch-clamp technique

Topic

An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.

laboratory techniques

patch-clamp techniques
voltage-clamp technique

Field 001 in MARC Authority Format

71056

Spanish

técnica de patch-clamp

URI

https://lod.nal.usda.gov/nalt/203622

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Created 8/19/13, last modified 12/6/13