NALT

Preferred term

anaphase promoting complex

Chemical

An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during mitosis through ubiquitination of specific cell cycle proteins. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the placenta, crystalline lens, and skeletal muscle, and in regulation of postmitotic neuronal plasticity and excitability.

ubiquitin-protein ligase

anaphase-promoting complex-cyclosome
anaphase-promoting complex/cyclosome

Field 001 in MARC Authority Format

62972

Spanish

complejo promotor de la anafase

URI

https://lod.nal.usda.gov/nalt/219107

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Created 6/19/14, last modified 5/1/20