NALT

Preferred term

CXCR3 receptor

Chemical

CD183 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to CD183. A hallmark of CD183 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that CD183 and its chemokines participate in the recruitment of inflammatory cells.

chemokine receptors

C-X-C chemokine receptor type 3
CD183 antigen
chemokine (C-X-C motif) receptor 3
chemokine (C-X-C) receptor 3
CKR-L2
CMKAR3
CXC chemokine receptor 3
CXCR3-A
CXCR3-B
GPR9 (G-protein coupled receptor 9)
I-TAC receptor
interferon-inducible protein 10 receptor
IP-10 receptor
MIG-R (Mig receptor)

Field 001 in MARC Authority Format

65663

Spanish

receptor CXCR3

URI

https://lod.nal.usda.gov/nalt/243568

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Created 3/10/15, last modified 11/16/15