NALT

Preferred term

etoposide

Chemical

A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

Field 001 in MARC Authority Format

66624

Spanish

etopósido

URI

https://lod.nal.usda.gov/nalt/262750

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Created 10/7/15, last modified 2/10/16