NALT

Preferred term

CRISPR-associated endonuclease 9

Chemical

An RNA-guided endodeoxyribonuclease that associates with CRISPR sequences in Streptococcus pyogenes and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small guide RNA (sgRNAs). Structurally, Cas9 consists of an alpha-helix module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand.

CRISPR-associated endonucleases

CRISPR-Cas systems

Cas9 endonuclease
Cas9 enzyme
Cas9 protein

Field 001 in MARC Authority Format

9813982864200041

Value previous used for Field 001 in MARC Authority Format

93682

Spanish

CRISPR proteína asociada 9

URI

https://lod.nal.usda.gov/nalt/329081

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Created 3/25/19, last modified 11/25/19