NALT

Preferred term

actinomycin D

Chemical

A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from Streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy.

dactinomycin

Field 001 in MARC Authority Format

834

Spanish

actinomicina D

URI

https://lod.nal.usda.gov/nalt/3814

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Created 1/19/06, last modified 11/17/17