@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .

<https://lod.nal.usda.gov/naltv#marc001> rdfs:label "Field 001 in MARC Authority Format"@en .
nalt:222855_def
  a <https://lod.nal.usda.gov/naltv#Definition> ;
  rdf:value "Receptor de insulina de la superficie celular, compuesto de un tetrámero de dos subunidades alfa y dos subunidades beta derivadas de la división de una única proteína precursora. Contiene un dominio intrínseco de tirosina quinasa localizado en la subunidad beta. Su activación mediante insulina produce numerosos cambios metabólicos, incluida una absorción mayor de glucosa en el hígado, los músculos y el tejido adiposo."@es, "A cell surface receptor for insulin. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic tyrosine kinase domain that is located within the beta subunit. Activation of the receptor by insulin results in numerous metabolic changes including increased uptake of glucose into the liver, muscle, and adipose tissue."@en ;
  dc:source "Medical Subject Headings 2014" .

<https://lod.nal.usda.gov/nalt>
  a skos:ConceptScheme ;
  rdfs:label "NALT Full"@en .

<https://lod.nal.usda.gov/naltv#Chemical>
  a owl:Class ;
  rdfs:label "Chemical"@en .

nalt:222855
  a skos:Concept, <https://lod.nal.usda.gov/naltv#Chemical> ;
  dc:created "2014-07-25"^^xsd:date ;
  dc:modified "2017-03-02"^^xsd:date ;
  skos:altLabel "insulin receptor protein-tyrosine kinase"@en, "insulin receptor beta subunit"@en, "insulin receptor beta chain"@en, "insulin receptor alpha subunit"@en, "insulin receptor alpha chain"@en, "insulin-dependent tyrosine protein kinase"@en ;
  skos:broader nalt:223462, nalt:146200 ;
  skos:definition nalt:222855_def ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  skos:narrower nalt:222943 ;
  skos:prefLabel "insulin receptors"@en, "receptores de insulina"@es ;
  skos:related nalt:294108, nalt:32965 ;
  ns0:marc001 "68379" .

nalt:294108
  a ns0:Chemical, skos:Concept ;
  skos:prefLabel "proteínas del sustrato receptor de insulina"@es, "insulin receptor substrate proteins"@en ;
  skos:related nalt:222855 .

nalt:222943
  a ns0:Chemical, skos:Concept ;
  skos:broader nalt:222855 ;
  skos:prefLabel "insulin receptor-related receptor"@en, "receptor relacionado con el receptor de insulina"@es .

nalt:146200
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:222855 ;
  skos:prefLabel "receptor de la proteína-tirosina quinasa"@es, "receptor protein-tyrosine kinase"@en .

nalt:223462
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:222855 ;
  skos:prefLabel "receptores de hormonas pancreáticas"@es, "pancreatic hormone receptors"@en .

nalt:32965
  a ns0:Chemical, skos:Concept ;
  skos:prefLabel "insulina"@es, "insulin"@en ;
  skos:related nalt:222855 .