@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .

<https://lod.nal.usda.gov/naltv#marc001> rdfs:label "Field 001 in MARC Authority Format"@en .
nalt:262750_def
  a <https://lod.nal.usda.gov/naltv#Definition> ;
  rdf:value "Derivado semisintético de la podofilotoxina que presenta actividad antitumoral. Inhibe la síntesis del ADN mediante la formación de un complejo con la topoisomerasa II y el ADN, que causa rupturas en el ADN bicatenario e impide la reparación por medio de la ligadura de la topoisomerasa II. La acumulación de rupturas en el ADN evita la entrada a la fase mitótica de la división celular y conduce a la muerte celular. El etopósido actúa principalmente en las fases G2 y S del ciclo celular."@es, "A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle."@en ;
  dc:source "Medical Subject Headings 2015" .

<https://lod.nal.usda.gov/nalt>
  a skos:ConceptScheme ;
  rdfs:label "NALT Full"@en .

<https://lod.nal.usda.gov/naltv#Chemical>
  a owl:Class ;
  rdfs:label "Chemical"@en .

nalt:262750
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  dc:created "2015-10-07"^^xsd:date ;
  dc:modified "2016-02-10"^^xsd:date ;
  skos:broader nalt:262755, nalt:3816 ;
  skos:definition nalt:262750_def ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  skos:prefLabel "etoposide"@en, "etopósido"@es ;
  skos:related nalt:255798, nalt:34181 ;
  ns0:marc001 "66624" .

nalt:255798
  a ns0:Chemical, skos:Concept ;
  skos:prefLabel "topoisomerase inhibitors"@en, "inhibidores de la topoisomerasa"@es ;
  skos:related nalt:262750 .

nalt:262755
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:262750 ;
  skos:prefLabel "podophyllotoxin"@en, "podofilotoxina"@es .

nalt:3816
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:262750 ;
  skos:prefLabel "agentes antineoplásicos"@es, "antineoplastic agents"@en .

nalt:34181
  a ns0:Topic, skos:Concept ;
  skos:prefLabel "daño al ADN"@es, "DNA damage"@en ;
  skos:related nalt:262750 .