@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .

<https://lod.nal.usda.gov/naltv#marc001previous> rdfs:label "Value previous used for Field 001 in MARC Authority Format"@en .
<https://lod.nal.usda.gov/naltv#marc001> rdfs:label "Field 001 in MARC Authority Format"@en .
nalt:329081_def
  a <https://lod.nal.usda.gov/naltv#Definition> ;
  rdf:value "An RNA-guided endodeoxyribonuclease that associates with CRISPR sequences in Streptococcus pyogenes and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small guide RNA (sgRNAs). Structurally, Cas9 consists of an alpha-helix module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand."@en, "Endodeoxirribonucleasa guiada por ARN que se asocia a secuencias de CRISPR en la bacteria Streptococcus pyogenes y otras bacterias en las que interviene en una función inmune adaptativa para adherir ADN extraño complementario a ARN guías. Estructuralmente, está compuesta por un módulo de hélice alfa y un módulo de nucleasa conectado por una única hélice. El módulo de nucleasa contiene dos dominios enzimáticos: RuvC, que corta la cadena de ADN no objetivo, y un dominio de nucleasa HNH, que corta la cadena objetivo."@es ;
  dc:source "Taken in part from: Medical Subject Headings" .

<https://lod.nal.usda.gov/nalt>
  a skos:ConceptScheme ;
  rdfs:label "NALT Full"@en .

<https://lod.nal.usda.gov/naltv#Chemical>
  a owl:Class ;
  rdfs:label "Chemical"@en .

nalt:329081
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  dc:created "2019-03-25"^^xsd:date ;
  dc:modified "2019-11-25"^^xsd:date ;
  skos:altLabel "Cas9 enzyme"@en, "Cas9 endonuclease"@en, "Cas9 protein"@en ;
  skos:broader nalt:329079 ;
  skos:definition nalt:329081_def ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  skos:prefLabel "CRISPR proteína asociada 9"@es, "CRISPR-associated endonuclease 9"@en ;
  skos:related nalt:329078 ;
  ns0:marc001 "9813982864200041" ;
  ns0:marc001previous "93682" .

nalt:329079
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:329081 ;
  skos:prefLabel "endonucleasas asociadas a CRISPR"@es, "CRISPR-associated endonucleases"@en .

nalt:329078
  a ns0:Topic, skos:Concept ;
  skos:prefLabel "sistemas CRISPR-Cas"@es, "CRISPR-Cas systems"@en ;
  skos:related nalt:329081 .